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The additional GIP component amplifies the GLP-1 effects rather than simply adding to them

Notably, serum tGSH (but not serum cystine) levels were lower in mice with tumours than in mice without tumours (Extended Data Fig

As an exploratory outcome, single doses of cotadutide led to dose-dependent improvement in glucose excursions post meals within 24 hours and food intake reduction from a single dose of 100 g

Additionally, metabolic adaptations that occurred during weight lossincluding decreased energy expenditure and hormonal changes that favor weight regainbecome more apparent once the medication's counterbalancing effects are removed

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