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The predominantly hepatic metabolism of orforglipron does, however, raise the question of whether dose adjustment is needed in hepatic impairment, an issue that was addressed in dedicated hepatic impairment studies during the clinical development program
Additionally, J&J submitted regulatory applications for Darzalex Faspro for high-risk smoldering multiple myeloma in both the US and the European Union (EU) in late 2024
It is imperative that people adhere to the advice of their healthcare professional with regard to dosage modifications in order to maximize weight reduction and minimize any possible adverse effects
however, the difference between the case and control groups was not significant
