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The steroidal MRAs spironolactone (first generation) and eplerenone (second generation) were the first to enter clinical practice and act as potassium-sparing diuretics with potent antihypertensive effects

An analysis of twin data

The non-erosive GERD approval was supported by a pivotal trial in which Voquezna quickly and significantly reduced heartburn with daily treatment compared to placebo over four weeks