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Obesity changes your muscle 'engine type': Excess weight shifts muscle fiber composition, reducing efficient, fat-burning Type I fibers and increasing less efficient, fatigue-prone Type IIx fibers, worsening metabolic flexibility

Independent of loss of kidney function, a rise in BUN may also occur as a result of hypercatabolism from the excess breakdown of amino acids

Do not determine the dose by counting clicks unless the original instructions specifically provide a validated click-based dosing guide