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The third body is in vivo rodent work, largely on muscle, bone, gut and neural tissue, some of it using the LR3 variant specifically because its altered clearance and reduced binding-protein capture change tissue exposure relative to native protein

Both drug classes exert pleiotropic effects on metabolic factors, such as obesity and hypertension

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therefore, it is too early to predict if GLP-1s will provide benefit for patients with these conditions