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Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2-deoxyguanosine

Our topical protocols use concentrations validated in clinical studies, applied alongside complementary ingredients that enhance penetration and efficacy

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Diet : those who follow vegetarian or vegan diets are more at risk due to limited B12 sources Pernicious anaemia : an autoimmune condition impacting stomach function Medication impact : certain medications (e.g., Metformin, Nitrous Oxide) Digestive conditions : disorders like Crohns Disease may affect B12 absorption Symptoms of a low Vitamin B12: Rapid breathing or shortness of breath Headaches Indigestion Loss of appetite Palpitations Problems with your vision Numbness Feeling weak or tired Diarrhea A sore or red tongue (sometimes with mouth ulcers) Problems with memory, understanding, and judgments (cognitive changes) Muscle weakness Depression Anxiety Confusion Dementia Problems with balance/coordination Pins and needles Incontinence If you suspect a Vitamin B12 deficiency, its essential to consult your GP for proper testing and treatment

After the removal of benzyl groups, the successful deprotection was confirmed with the percentage of the remaining benzyl groups lower than 5% based on the 1 H NMR data (Fig