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As GPX4 is known to suppress ferroptosis, an iron-dependent and ROS-reliant cell death 39 (Fig
In patients with chronic pancreatitis there is clear evidence of oxidant-associated breakdown in methionine metabolism
Carnitine network and alterations Carnitine distribution is highly variable across tissues, ranging from low millimolar levels in most tissues to the highest (60 mM) in the testes
Mediator subunit MDT-15 promotes expression of propionic acid breakdown genes to prevent embryonic lethality in Caenorhabditis elegans
These findings were further corroborated within the Lifelines Cohort, where results showed sex- and duration-specific DNA methylation changes in women exposed to intermediate-term NSW (10-16 years), enriched in pathways related to circadian regulation and cellular senescence
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