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When someone goes from eating 2,200 calories a day to eating 1,300, the margin for nutritional error shrinks enormously
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Furthermore, in participants with T2D, treatment with the selective long-acting GIP receptor agonist, macupatide, was associated with a larger insulin sensitivity improvement compared with the selective GLP-1 receptor agonist dulaglutide, despite similar body weight reduction, and combination therapy with these agents was associated with additive effects on insulin sensitivity [20]
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