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Such an integrated approach supports a more holistic and potentially preventive strategy for addressing both the immune and metabolic components of the disease
Disease Modification Potential While GLP-1 medications dont cure diabetes, they may modify disease trajectory: Preserved beta cell function: Some evidence suggests GLP-1 medications may help preserve pancreatic beta cells, potentially slowing disease progression
Potential Risks GLP-1 medications have shown promise in reducing the severity of OSA through weight loss and related physiological changes
Anti-inflammatory effects via CD38 inhibition Higher NAD+ levels can inhibit CD38 through feedback and thereby reduce chronic inflammation (inflammaging)
5.2 Reduction of oxidative stress and endoplasmic reticulum stress Chronic hyperglycemia and endothelial activation drive excessive generation of ROS, promoting mitochondrial dysfunction, endothelial apoptosis, and reduced NO bioavailability
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