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These drugs mimic the binding of the naturally produced GLP-1 hormone to its cognate receptor after food intake, which has the effect of regulating glucose homeostasis, lipid metabolism, gastric emptying and feelings of satiety 19 (Figure 1)

Mitochondrial dysfunction and mitophagy failure in NDDs Mitochondrial dysfunction is a defining molecular hallmark across NDDs

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The synthesis of PRPP by PRPP synthetase is feed-back inhibited by purine-5-nucleotides (predominantly AMP and GMP)

Justin Marchegiani: I wanted to highlight this one study here so you can see it to kind of just dovetails with everything we're talking about