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Although GCs are important in maintaining lipid homeostasis, an excess of GCs can lead to an increase in circulating free fatty acids and cause lipid accumulation in skeletal muscle and liver also associated with insulin resistance [80]

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Source: GLP-1.Reviews editorial walkthrough on April 13, 2026

The FDA notes that Zepbound will be approved for those whose body mass index (BMI) a widely criticized standard is 30 or greater, qualifying them as obese

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