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Hypoxia-inducible factor 1 (HIF-1) is a crucial transcription factor modulating the high energy requirements of immune cells to perform their effector functions in low-oxygen states (6770)
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If H 2 O 2 remains in the mitochondrial matrix it reacts with the ferrous (Fe 2+ ) iron via the Fenton reaction yielding the hydroxyl free radical which is highly reactive toward DNA and polyunsaturated fatty acids (PUFA)
10.1038/s41536-024-00368-w 122 RamosSebastianA.GwakS.KimS
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