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In a study of transgenic mice with a Kras G12D mutation which induces PanINs and eventually pancreatic cancer, treatment with exendin-4 increased higher grade PanIN lesions (35, 38)
This selectivity provides lipolytic benefits with minimal cardiovascular stimulation or systemic side effects
[1] Contact your GP or NHS 111 if: Gastrointestinal side effects persist beyond the first few weeks or worsen over time Diarrhoea persists for more than a few days or is accompanied by fever Constipation becomes severe or does not respond to dietary measures and over-the-counter remedies You experience unexplained weight loss beyond expected therapeutic effects Symptoms significantly impact your quality of life or ability to maintain nutrition You have concerns about any new or unusual symptoms Patients with known diverticular disease should maintain regular contact with their healthcare team and report any changes in bowel habits or abdominal symptoms promptly
Adjust the dosage based on the animal's weight, age, and health condition
These effects are real and can be significant in the short term
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