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The nasal mucosa is highly vascularized, allowing absorption directly into circulation, and some evidence suggests nasal administration may provide more direct central nervous system access via the olfactory pathway
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To quantitatively evaluate the movement of para-arterial CSF tracer, mean fluorescence intensity (ROI) was measured at 100 m below the cortical surface over 30 min with intervals of 5 min (Fig
& Kouroumalis, E
Active malignancy is a contraindication because NAD+ supports cellular proliferation
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