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Chondrocyte dedifferentiation was majorly characterized as the reduced expression of COL2 and ACAN and enhanced expression of type I collagen and versican ( COL2 expression, but not ACAN ( In addition to dedifferentiation, another consequence of in vitro expansion is replicative senescence, which also significantly influences chondrocyte function

In comparison, the mean blood mercury concentration of children with autism was 19.53 nmol/L

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However, in clinical trials targeting severe cognitive impairment, chronic fatigue syndrome, or neuropathy, therapeutic doses usually range from 1,500 mg to 3,000 mg (1.5g 3g) daily