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When insulin sensitivity improved through exercise or bariatric surgery, NNMT levels in adipose tissue fell suggesting NNMT activity tracks with metabolic state rather than being a passive marker
Core Mechanisms Recap: NNMT Inhibition: Prevents NAD depletion, supporting energy production and metabolic flexibility
this was not included in the tool since the definition of outliers is subjective
By boosting GLUT4, 5-amino-1MQ appears to encourage adipocytes to produce a distinct class of lipids called PAHSAs (palmitic acid esters of hydroxy-stearic acids)
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