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As deduced from molecular modeling, 15 and Ang IV seem to adopt a -turn at the C-terminal when binding to IRAP, while in the case of 21 , a less well-defined turn conformation is adopted at the N-terminal

02 Add one piece of context If it matters, tag a cue such as stress, boredom, hunger, poor sleep, or seeing food

The likely reason, she explained, is that these drugs act on the same reward circuitry that drives food cravings, so when those circuits become less reactive, other urges can ease, too

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