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The trial tested oral administration primarily, and no controlled study has tested subcutaneous injection in humans
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How GLP-1 And Semaglutide Act In The Human Body Both natural GLP-1 and semaglutide target GLP-1 receptors in different parts of the body
Compensatory secretion of growth hormone/insulin and activation of InsR While growth hormone stimulates IGF1 synthesis, activation of IGF-IR/InsR by IGF feeds back to inhibit growth hormone synthesis [27]
![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/profile/Asfandyar-Sheikh/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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