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On May 1, 2025, Eli Lilly announced that it withdrew its FDA application for Zepbound (tirzepatide) for the treatment of HFpEF in patients with obesity, stating that the FDA requires an additional confirmatory trial to support the application

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doi: 10.1227/01.NEU.0000143617.25417.68 47 SolomonRAHandlerMSSedelliRVSteinBM

Stimulating GLP-1R in BMSCs triggers the buildup of nuclear -catenin, which, in turn, activates osteogenic genes by binding with TCF7L12

Practices may wish to assess frail patients on an individual basis to determine the appropriate frequency of monitoring