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Target Engagement DSIP does not exhibit a clearly defined high-affinity binding profile to a single receptor system, which distinguishes it from many receptor-specific peptide ligands

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One key difference: tirzepatide is a dual GIP/GLP-1 receptor agonist, while semaglutide targets only GLP-1

In addition, genome editing is an approach in which a specific target gene can be engineered by adding, deleting or replacing the nucleotides