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Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity Proc Natl Acad Sci USA 2013;110(22):9066-9071 doi:10.1073/pnas.1219451110 (Animal study, mice) Depommier C, Everard A, Druart C, et al
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The dosing schedule of retatrutide is as follows: Weeks 1-4: 1 mg or 2 mg once weekly (starting dose) Weeks 5-8: 4 mg once weekly Weeks 9-12: 8 mg once weekly Week 13+: 8 mg or 12 mg once weekly (Maintenance Dose) However, some trial arms tested higher doses (up to 8 mg or 12 mg as the final dose)
Jan 9, 2026 10 min read IN THIS ARTICLE KEY TAKEAWAYS Weight loss can include muscle loss, not just fat loss
It has been studied in both oral and injectable forms
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