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GLP-1 receptor agonists are established for blood sugar control and weight loss, but research is expanding into areas like IBS, appetite regulation, and PCOS
This makes it an excellent choice for athletes, fitness enthusiasts, and those with chronic pain conditions
People with higher starting BMIs tended to continue losing weight for longer before plateauing
TRIUMPH-3: Obesity with Established Cardiovascular Disease (July 2026) TRIUMPH-3 enrolled 1,949 adults with severe obesity (BMI 35) and established cardiovascular disease, with or without type 2 diabetes, randomized 1:1:2 to retatrutide 9mg, 12mg, or placebo over 80 weeks
Increasing water intake slightly can help
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