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7 Limitations and future prospects The clinical translation of morin and similar phytochemicals faces significant challenges, including poor bioavailability, limited human pharmacokinetic data, and natural product variability
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In parallel, studies have reported modulation of early growth response-1 (EGR-1) expression and its regulatory partner NAB2, which are involved in cytokine signaling and early extracellular matrix formation during cellular response processes [2]
These observations were also made with mechanistically different secondary stressors such as the mitochondrial complex I inhibitor, rotenone, or proteasomal inhibitors such as MG-132 or bortezomib (Suppl
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