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Preliminary evidence suggests that weight regained after stopping a GLP-1 treatment is more likely to come back as fat than as lean mass

Gallbladder concerns: Retatrutide showed a 2.4% rate of gallbladder-related adverse events over 68 weeks

51 The lung is particularly at risk from oxidative damage as it is exposed to oxygen, oxygen radicals produced by alveolar macrophages, inhaled environmental and blood-borne toxins, including cigarette smoke and atmo-spheric pollutants

J Clin Endocrinol Metab 33(3):382387 Sahpazidou D, Geromichalos GD, Stagos D, Apostolou A, Haroutounian SA, Tsatsakis AM, Tzanakakis GN, Hayes AW, Kouretas D (2014) Anticarcinogenic activity of polyphenolic extracts from grape stems against breast, colon, renal and thyroid cancer cells

Treatment length varies depending on your health, weight loss goals, and how your body responds