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While SGLT-2is (e.g., empagliflozin, canagliflozin) and DDP-4is (e.g., sitagliptin) are exclusively available as orally administered medications, both oral and subcutaneous formulations of the GPL-1RA semaglutide are available
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Additionally, DSIP appears to be regulated by glucocorticoids, and its signaling may interact with the MAPK cascade through homology with glucocorticoid-induced leucine zipper (GILZ), suggesting potential roles in cellular stress responses
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