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(2011) 6:e23354

Currently, effective treatments for insomnia include cognitive behavioral therapy (CBT-I) and pharmacotherapy [22] but remain of concern due to cost-effectiveness concerns and drug dependency [23]

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Acknowledgements The authors thank members of the Zhang laboratory and George Mentis at Columbia University for scientific inputs and helpful discussions during this study, the Columbia Transgenic Mouse Core Facility for producing Ank3 E35a / mice, and the Columbia Neurobehavior Core Facility for assisting with behavior analyses