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Comparative transcriptome analysis reveals that exendin-4 improves steatosis in HepG2 cells by modulating signaling pathways related to lipid metabolism

Early research suggests transdermal GLP-1 delivery may provide consistent hormone levels, though clinical efficacy varies significantly based on individual biomarkers, baseline metabolic health, and adherence patterns

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For instance, the administration of GLP-1 nanomedicine resulted in a decrease in IL-1, a pro-inflammatory cytokine, and a marked improvement of the architecture of the intestinal epithelium in a colitis model [223]