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Treatments in these co-cultures included PBS as a control, FOXO4-DRI at 50 M, hydrogen peroxide (H2O2) at 50 M to induce senescence, and a combination of H2O2 with FOXO4-DRI
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Stimulating effects of H 2 S on glycolytic metabolism in cancer cells have been demonstrated to result from per-sulphidation of lactate dehydrogenase (LDH, particularly the LDH-A isoform) 149,150 and glyceraldehyde-3-phosphate dehydrogenase, although the functional consequences of per-sulphidation of the latter appear to be controversial
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