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In einer fruehen Pilotstudie zeigten unter topischer Anwendung eines Kupfertripeptid-Komplexes 7 von 10 Probandinnen eine Zunahme der Prokollagen-Synthese, verglichen mit 5 von 10 unter Vitamin C und 4 von 10 unter Tretinoin (Retinsaeure) als Referenzsubstanzen (Abdulghani et al., 199800011-4))

For preclinical tissue models, stronger evidence would require standardized injury models, blinded outcome assessment, histological confirmation, functional endpoints, and comparison against appropriate positive and negative controls

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