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l-Carnitine Supplementation in Recovery after Exercise [published correction appears in Nutrients

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Specifically, downregulated heat shock protein A12A (HSPA12A) in hepatocytes increases glycolysis and lactate production, which leads to HMGB1 lactylation and exosomal secretion of hepatocytes, exacerbating hepatocyte damagemacrophage chemotaxis/activation

The nervous system is flooding the body with norepinephrine and epinephrine, which creates sensations that feel emotional but are entirely physical in origin

This suggests that the antioxidant response provided by NRF2 is not required for liver survival in the absence of GSH