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There are several forms of B12 on the market: Hydroxocobalamin is the NICE-recommended, prescription-only form used by the NHS and qualified medical practitioners
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CTD-ACTD dossier support: Full eCTD and ACTD modules, ICH Q1A long-term and accelerated stability data, ICH Q1B photostability data, drug master files and CEP-style documentation for registrations including ministry-of-health, hospital-formulary and institutional tenders
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The most common causes include B12 supplementation (particularly injections), liver disease releasing stored B12, haematological disorders increasing B12-binding proteins, and chronic kidney disease reducing B12 excretion
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