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The increase in PyroGlu could be due to three key points: (I) the catabolism of GSH through gamma-glutamyl transpeptidase, (II) and/or to a limiting factor in the second step of gamma-glutamylcysteine synthetase (III) or a limiting factor in the following step involving glutathione synthetase
Low red blood cell counts may indicate deficiency
Detection of glutathione S-transferase isozymes after electrofocusing in [PMID: 7316165] Laboratory literature summary: Detection of glutathione S-transferase isozymes after electrofocusing in polyacrylamide gels
Ongoing monitoring for any unexpected effects remains prudent
The best-known are: Vilon Lys-Glu (a dipeptide), associated in the literature with the thymus/immune line of research
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