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Novel MitoXcel-Powered Geropeptide Platform Our MitoXcel Geropeptide Lead Clinical Candidates PTC-2105 and PTC-2107, Are: 18- to 30-amino acids in length Cross the blood brain barrier Administered via SC injection over an 8-16 week, and longer, course of treatment in pre-clinical models Key Findings: Selective Elimination of Senescent Cells: In all organs of the body, including the brain, in a dose dependent manner Reduced Systemic Inflammation: Significant decrease in SASP biomarkers Tissue Remodelling to a Healthier Phenotype in Muscle and Fat: Improved body composition including a reduction in fat but an increase in lean body and bone mass Improved Physical Health: Enhanced metabolism, muscle strength, and exercise endurance

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Analytic Approach National all-payer claims data were used to examine patient volumes for bariatric weight loss surgery, cardiac catheterization, GLP-1 medication use and SGLT2 inhibitor medication use from 2018 to 2023

Efficacy and Safety of GLP-1 Agonists on Metabolic Parameters in Non-diabetic Patients with Inflammatory Bowel Disease

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