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The other factors inducing reduced appetite is mediated by butyrate and propionate by (i) enhanced expression of leptin in adipocytes, direct regulation of body weight and energy homeostasis by decreased food intake and upregulated energy expenditure [31], (ii) promoting gluconeogenesis in the intestinal cells [32] and (iii) inhibition of histone acetyltransferase and deacetylases which exhibit anti-inflammatory responses, epigenetic modification necessary for proliferation and differentiation of immune cells, activated AMP-activated protein kinase (AMPK) pathway synchronised adiponectin secretion, induction of mitochondrial biogenesis and fatty acid oxidation [33]
Contraindications include certain thyroid conditions, MEN2, or active pancreatitis
Alcohol may worsen common GLP-1 side effects including nausea, vomiting, and gastrointestinal discomfort
A single "yes" warrants in-person evaluation before starting a GLP-1 agent through any telehealth platform
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