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Transcriptomic studies combined with metabolomic studies have defined GLS1 as a marker enzyme of fibroblast-like synoviocytes (FLS) isolated from RA patients (93)
Ex9 and linagliptin administered together to VilCre control mice but not Gcg RA VilCre or Gcg RA Null mice produced elevated basal glucose (15 min) and all mice had a significantly lower glucose excursion compared with Ex9 treatment alone at 1560 min after the glucose load
None of these ranges are validated clinical doses
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