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The number you see each morning measures everything at once (fat, muscle, water, undigested food, inflammation, glycogen stores), creating measurement noise that can hide two or three pounds of actual fat loss behind five pounds of temporary water retention
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This article summarises the position reached with the GLP-1 RAs and reviews the developing field of unimolecular co-agonists that act not only on the GLP-1 receptor, but on other receptors, notably glucose-dependent insulotropic polypeptide (GIP) and glucagon receptors, with the aim of further improving glycaemic control and weight reduction
The glucose-dependent mechanism means that when blood sugar levels are normal, insulin secretion is not excessively stimulated, providing a safer metabolic profile than some older diabetes treatments
