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Phase 1b/2a Subcutaneous Formulation (Obesity) Published: The Lancet, June 2025 Participants: 125 adults with overweight or obesity (BMI 27.039.9), aged 1855 Duration: Up to 36 weeks Dosing: Once-weekly subcutaneous amycretin, up to 60 mg Results: - Up to 22% absolute weight loss at 36 weeks (highest dose group) - Placebo-adjusted difference: approximately 24% - No weight-loss plateau observed at study end Safety: 81% of the 89 participants who reported a TEAE had gastrointestinal events

What this means for you If your top priority is the strongest possible A1C reduction in type 2 diabetes, your clinician may consider tirzepatide

Several early-phase studies are exploring synergistic pairings of epigenetic modulators, ICBs, DNA damage response agents, and targeted therapies across diverse cancer types

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Because retatrutide represents a major evolutionary leap over existing therapies, its commercial launch will likely disrupt the entire metabolic market