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LEAP2 suppresses appetite in both rodents and humans, and optimized analogs have shown modest but promising metabolic effects in preclinical models

Additionally, dietary antioxidants derived from fruits, vegetables, and other plant sources play a significant role in maintaining the redox balance [16]

In clinical trials, discontinuation rates due to gastrointestinal adverse effects ranged from 3-7%, indicating that whilst most patients can tolerate these symptoms, they can be sufficiently troublesome to necessitate treatment cessation in some cases

The STEP program added thousands more participants focused specifically on weight management

Even the lowest dose of 5 mg produced 15% weight loss