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Dogs receiving high-calorie intake (120% MER) exhibited a dose-dependent reduction in feed consumption and significant body weight decrease at doses of 236 mg and 492 mg of L-carnitine, independent of exercise, and this was mostly found in females

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For genetically predicted acetyl-carnitine, we also found an association with higher triglycerides (0.06, 95% CI 0.04 to 0.07) and lower HDL-cholesterol ( 0.03, 95% CI 0.05 to 0.02) (Additional file 2: Fig