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Tirzepatide bypasses this issue by heavily engaging GIP receptors, which are encoded by a separate gene (GIPR)

While both of these medications can be effective at controlling blood glucose levels, they can also have side effects, and taking them together may increase the risk of certain adverse and unwanted effects

This 25 fold difference matters clinically because weight loss efficacy in trials shows a dose-response relationship: higher, sustained GLP-1 levels correlate with greater appetite reduction and metabolic rate improvements

This process makes it essential to have a plan for weight management after GLP-1 medications

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