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doi: 10.1210/me.2005-0479 57 HeemersHVerrijdtGOrganeSClaessensFHeynsWVerhoevenGet al
The activity of MC4R is strictly regulated by its endogenous ligands: -melanocyte-stimulating hormone (-MSH) binds to MC4R and transmits anorexigenic and energy-expenditure signals, whereas agouti-related protein (AgRP) exerts an antagonistic effect by binding to the receptor, competitively inhibiting -MSH action and promoting appetite
Andraos J, Smith SR, Tran A, Pham DQ
