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3) There is a risk you will overdose if we give it too early (the GP)

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The decision to continue, adjust, or discontinue therapy should be based on objective body composition measurements (DEXA scans, circumference measurements), achievement of fat loss goals, tolerance and side effect profile, and physician assessment of metabolic markers

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Reference lists of included studies and relevant reviews were screened manually to identify additional eligible studies

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reduced NNMT may shift these patterns toward a more metabolically active state

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