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Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program

Met Ions Biol Syst 36:139 Stohs SJ, Bagchi D (1995) Oxidative mechanisms in the toxicity of metal ions

L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress

It doesnt negatively affect the bodys hormonal balance, but rather gives the endocrine system a boost to do what its naturally built to do, just better and more efficiently