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This side effect is often dose-dependent and may be more pronounced when starting treatment or increasing the dosage

MAPK signaling contributes to therapeutic resistance by enhancing the expression of drug efflux transporters such as MDR1 and P-gp and by upregulating antiapoptotic genes such as Bcl-2

Liver enzymes (ALT/AST) when dose increases happened

The prevalence data in Taiwan show an increase in prevalence from 21.8 per 100,000 in 2002 to 40.2 per 100,000 in 2013, while in China, the rates are relatively lower, estimated at 21.8100 cases per 100,000 (Li et al., 2022

Because BPC 157 is based on a peptide fragment found in gastric juice, it has been studied for protective effects on the stomach and intestinal lining in preclinical models