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Men Who Cannot Take PDE5 Inhibitors: There are individuals who are unable to use PDE5is due to contraindications most notably, those who take nitrate medications (for angina or heart disease) or certain alpha-blockers

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[14] [15] Key contraindications and cautions include chronic kidney disease, heart failure, peptic ulcer disease, and elevated cardiovascular risk all of which may be relevant in patients with obesity or metabolic syndrome