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After extensive experiments, MC3181 was deemed the more promising compound of the two, due to it having a 50-fold rise in aqueous solubility and higher selectivity toward GST
This revelation reveals exciting possibilities in the realm of drug discovery, as GST inhibitors and its prodrugs offer a feasible strategy in designing anticancer drugs with the primary purpose of reversing tumor resistance
Cysteine is usually the rate-limiting amino acid, linking glutathione production directly to dietary protein, cysteine availability and transsulfuration
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