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Reconstitution Solution ensures multiple, sterile withdrawals from the vial without the risk of bacterial contamination, ideal for researchers handling peptides and other reagents
The novel peptide is biased towards GLP-1R agonism versus GCGR with a 3-4 fold reduced potency at the GLP-1R compared to native GLP-1 and around an 8-fold reduced potency at the GCGR compared to native glucagon
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Finally, the rigid helical (EAAAK) 3 was used as the linker to maintain the spatial distance between the domains and their independent functions (Fig
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