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Some researchers report success with freezing at -20 degrees Celsius, but this introduces a variable that could compromise results

To assess the presence of residual/unmeasured confounding, we chose kidney stone as a negative control outcome and repeated the analysis, as there is no known effect of GLP-1RA on kidney stone

We entered overlapping DEGs as a query signature in the CMap database and the top ten small-molecule drugs are listed in Table 1

3 Extensively publicized reports of ocular adverse events, such as nonarteritic anterior ischemic optic neuropathy (NAION), have been challenging to assess due to confounding health factors and conflicting evidence