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glucagon component may cause transient heart rate increase Tirzepatide : GI side effects common but well-characterized

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Damage to the lining of the stomach and small intestine results in symptoms that range from relatively minor heartburn, nausea, and abdominal pain (affecting 15-40% of NSAID users) to the life-threatening ulceration, perforation, and bleeding (affecting 1-2% of chronic NSAID users) (Vonkeman 2010)

PubMed 37364590 Regulatory status: Cagrilintide is not an approved human medicinal product in any regulatory zone (FDA, EMA, KL) as of the publication date

95% CI: 0.370.91)