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The analysis looked at electronic health records from more than 600,000 U.S

doi: 10.1016/j.jand.2013.09.016

It notes the gastrointestinal effects are most common during titration and often improve with slower dose escalation managed by a provider

Use of the modified Atkins diet for treatment of refractory childhood epilepsy: a randomized controlled trial

The medication can increase both systolic and diastolic blood pressure by 2-4 mmHg on average, with heart rate increases of 3-6 beats per minute being commonly reported